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Green Equipment and Technology
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Green Equipment and Technology
- The Use of PAT to Improve Product Sustainability
- Process Integration
- On-Line Mathematical Modeling of PAT data
- Evaluation of benefits for drug substance continuous manufacturing
- Develop a more detailed and real-world representative ROI analysis for e2e manufacturing
- Assess the feasibility of laser induced crystallization in microspheres
- Assessing the impact of biopharmaceutical processing on the carbon footprint and
how different technologies present different outcomes. (Aligned to the existing
work on the bio harm value chain sustainability roadmap)
- Identifying methods of reducing the impact of disposable biopharmaceutical processing
technology on the environment (e.g. disposable bio-reactors)
- Addressing the challenge of the cold supply chain required to support biopharmaceutical
products
- Demonstrate both the ability to scale up the production of controlled API microspheres
and the tunability of the platform in the production of single and co-formulated
crystalline API drug product
- Automate the development of drug product formulations through the use of models
that predict compatibility and dissolution profile with a standard set of excipients
based on the physical and chemical properties of the API, combined with tableting
equipment with built-in analytics that can automatically iterate to a final drug
product formulation meeting the required specifications (which would be part of
the input to the development algorithm)
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When considering a submission, please review the problem statements which highlight
some of the challenges faced within the pharmaceutical and fine chemicals industries.
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